Squalid. You live in a leaky stable, a mud-floored hut just outside town, or a vermin-infested boarding house in the worst part of town. You have shelter from the elements, but you live in a desperate and violent Environment, in places rife with disease.
Political. A politcial enemy might inlcude a local magistrate, a noble who rules the region, or a monarch ruling the kingdom. the NPC might have offended a local ruler,become an outlaw, or a be a political rival.